Gina M. Many

In 174 sedentary adults, resistance exercise changed more muscle molecular features than endurance exercise across omes and time points; network analysis nominates MEF2A and NFIC as regulatory hubs.

The paper analyzes multi-omic, multi-tissue molecular responses to acute exercise in sedentary adults, identifying key pathways and exerkines involved in exercise effects.

The paper identifies shared and distinct biochemical responses to different exercise modes through plasma proteomics, metabolomics, and transcriptomics in sedentary humans.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

The paper examines the association between skeletal muscle gene expression and knee osteoarthritis in older adults using bulk RNA sequencing from the SOMMA study.

The paper profiles multi-omic changes in abdominal subcutaneous adipose tissue after acute exercise in sedentary adults, identifying distinct molecular programs and candidate exerkines.

This study shows that activating AMPK alpha2 T172 in skeletal muscle improves exercise performance and energy transduction, and its disruption mimics type 2 diabetes features.

This study shows calorie restriction delays type 1 diabetes onset in NOD mice by enhancing glucose homeostasis and promoting a pro-tolerogenic islet microenvironment through increased PD-L1 expression.

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

This paper introduces a fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis, demonstrating its utility in identifying EV proteins related to physical activity.

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.