Charles Burant

In 174 sedentary adults, resistance exercise changed more muscle molecular features than endurance exercise across omes and time points; network analysis nominates MEF2A and NFIC as regulatory hubs.

The paper presents initial findings from the MoTrPAC consortium, showing that acute and chronic exercise induce distinct physiological and molecular responses, with chronic training improving key health metrics.

The paper analyzes multi-omic, multi-tissue molecular responses to acute exercise in sedentary adults, identifying key pathways and exerkines involved in exercise effects.

The paper identifies shared and distinct biochemical responses to different exercise modes through plasma proteomics, metabolomics, and transcriptomics in sedentary humans.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

This study examines how acute endurance and resistance exercise alter alternative splicing in human skeletal muscle, adipose tissue, and blood, identifying 5102 differential splicing events and their regulatory mechanisms.

The paper identifies enhancer architecture differences in skeletal muscle between high and low cardiorespiratory fitness rats, linking them to gene expression and metabolic traits.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

This study compares the acute effects of three exercise intensities on subcutaneous adipose tissue transcriptome in regular exercisers, finding intensity-specific gene expression changes and common pathways involved in cardiometabolic health.

The paper identifies β-oxidation as a key process in noise-induced hearing loss using lipidomics profiling and validates it with Etomoxir treatment.

This study identifies reduced insulin-mediated suppression of fatty acid release and altered skeletal muscle lipid droplet characteristics as predictors of insulin resistance in adults with obesity.

This paper introduces INTERFACE, a probabilistic fine-mapping method that improves the identification of causal genes by integrating colocalization and transcriptome-wide association evidence.

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

The paper introduces Multi-INTACT, a method that integrates transcriptome-wide association studies with protein QTL data to identify causal genes for metabolites, finding that both gene products are relevant for most gene nominations.

The paper performs population-scale single-nucleus multi-omic profiling of skeletal muscle to identify genetic regulation across cell types and traits.

This study identifies 1,289 genetic signals for type 2 diabetes in 2.5 million individuals, revealing distinct clusters linked to vascular complications and highlighting ancestry-specific genetic risk factors.

This study maps multi-omic mitochondrial changes across 19 tissues in rats after endurance exercise training, identifying tissue-specific adaptations and disease-related hubs.

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

This study identifies 303 novel genetic signals associated with plasma metabolites in Finnish men, revealing biological insights into disease mechanisms.

The paper integrates snATAC-seq and snRNA-seq data from human and rat skeletal muscle to identify cell types, regulatory elements, and SNPs associated with complex traits.