This paper develops a nanoplatform using red blood cell-derived extracellular vesicles to deliver Cetuximab and cisplatin, enhancing cancer cell killing and reducing toxicity in triple-negative breast cancer.

Journal of Nanobiotechnology · Jun 7, 2026Peer-reviewedCell Biology

Membrane Sensing Peptides -Enhanced SiMoA Platform for the Detection of HER2 on Extracellular Vesicles in Metastatic Breast Cancer Patients

Arianna Bonizzi, Paola Gagni, Francesca Piccotti, Marta Truffi, Sara Albasini, Serena Mazzucchelli, Lorena Signati, Tiziana Triulzi, Elda Tagliabue, Alessandro Gori, Giorgia Esposito, Francesca Gorgoglione, Ilaria Tagliolini, Fabio Corsi, Carlo Morasso

This paper introduces an enhanced SiMoA platform using membrane sensing peptides to detect HER2 on extracellular vesicles in metastatic breast cancer patients, showing improved sensitivity and prognostic relevance.

bioRxiv · Sep 18, 2025 · PreprintBiochemistry

Exploring Breast Cancer-Related Biochemical Changes in Circulating Extracellular Vesicles Using Raman Spectroscopy

Arianna Bonizzi, Lorena Signati, Maria Grimaldi, Marta Truffi, F. Piccotti, Stella Gagliardi, Giulia Dotti, Serena Mazzucchelli, Sara Albasini, Roberta Cazzola, Debanjan Bhowmik, Chandrabhas Narayana, Fabio Corsi, Carlo Morasso

This study uses Raman spectroscopy to analyze biochemical changes in circulating extracellular vesicles between breast cancer patients and healthy controls, identifying distinct signatures of nucleic acids and lipids in cancer samples.

Biosensors and Bioelectronics · Feb 19, 2025Peer-reviewedBiophysics