This paper develops a nanoplatform using red blood cell-derived extracellular vesicles to deliver Cetuximab and cisplatin, enhancing cancer cell killing and reducing toxicity in triple-negative breast cancer.

Journal of Nanobiotechnology · Jun 7, 2026Peer-reviewedCell Biology

5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes

Cristina Cosentino, Rémy Klein, Véronique Menoud, Claudiane Guay, Elena Aiello, Stefano Auddino, Gianfranco Di Giuseppe, Gea Ciccarelli, A. Galli, Francesco Alabiso, Eleonora Mangano, Flora Brozzi, Karim Bouzakri, Stefania D’Adamo, Silvia Cetrullo, , Romano Regazzi

This study identifies 5'tRNA-derived fragments as mediators of β-cell dysfunction and islet macrophage activation in type 2 diabetes.

Nature Communications · May 4, 2026Peer-reviewedCell Biology

Small non-coding RNA profiling reveals inflammatory and mitochondrial related changes in aging β-cells and islet macrophages

Claudiane Guay, Jérôme Perrard, Eleonora Mangano, Véronique Menoud, Elena Aiello, Daniela Fignani, Francesco Dotta, Susan Bonner‐Weir, Guido Sebastiani, Cristina Aguayo‐Mazzucato, Cristina Cosentino, Romano Regazzi

This study profiles small non-coding RNAs in aging β-cells and islet macrophages, identifying age-related changes in miRNAs and tRFs linked to inflammation and mitochondrial function.

bioRxiv · Dec 18, 2025 · PreprintMolecular Biology

INTEGRATE: Model-based multi-omics data integration to characterize multi-level metabolic regulation

Marzia Di Filippo, Dario Pescini, Bruno G. Galuzzi, Marcella Bonanomi, Daniela Gaglio, Eleonora Mangano, Clarissa Consolandi, Lilia Alberghina, Marco Vanoni, Chiara Damiani

INTEGRATE integrates metabolomics and transcriptomics data to identify metabolic flux regulation at the enzyme expression and metabolic levels in cancer cell lines.

PLoS Computational Biology · Feb 7, 2022Peer-reviewedSystems Biology