On-lamella super-resolution cryo-CLEM for cryo-ET enabled by vacuum-free ultra-stable cryogenic fluorescence microscopy
Julian Falckenhayn, Vi Quint Duong, Neeraj Prabhakar, Iain Harley, Enoch Lok Him Yuen, Tolga O. Bozkurt, Stephen D. Carter, Vojtěch Pražák, Rainer Kaufmann
This paper introduces VULCROM, a vacuum-free cryogenic fluorescence microscope that enables high-resolution cryo-SR-CLEM and detailed single-molecule studies in vitrified specimens.
bioRxiv · Apr 15, 2026 · PreprintBiophysics