Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity
Ashley Rider, Henry J. Grantham, Graham R. Smith…·Nick J. Reynolds
Author
Royal Victoria InfirmaryORCID 0000-0002-6484-825XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
Recent·Most cited
Ashley Rider, Henry J. Grantham, Graham R. Smith…·Nick J. Reynolds
Ariana Hernández-Cordero, Laurent F. Thomas, Alice Smail…·Francesca Capon
This paper conducts a genome-wide meta-analysis of palmoplantar pustulosis, identifying genetic associations with Th2 responses and cigarette smoking.
Ruoyan Li, Johanna Strobl, Elizabeth F. M. Poyner…·Muzlifah A. Haniffa
The paper identifies Th2-like malignant cells in CTCL supported by a B cell-rich microenvironment through single-cell and spatial transcriptomics analysis.
Fedor Shmarov, Graham R. Smith, Sophie C. Weatherhead…·Paolo Zuliani
This paper develops a personalisable computational model of psoriasis that simulates immune interactions and predicts individual patient response to UVB therapy.
Marta Vergnano, Maja Mockenhaupt, Natashia Benzian-Olsson…·Angela Pushpa‐Rajah
The paper identifies MPO mutations as genetic determinants of pustular skin disease and increased neutrophil counts through exome sequencing and UK Biobank analysis.
Adam Richardson, Andrew K. Powell, Darren W. Sexton…·Kehinde Ross
The paper shows that extracellular calcium induces miR-184 via SOCE in keratinocytes, which promotes differentiation by regulating cyclin E and DNA damage markers.