The paper identifies Th2-like malignant cells in CTCL supported by a B cell-rich microenvironment through single-cell and spatial transcriptomics analysis.

bioRxiv · Nov 6, 2023 · PreprintGenomics

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

Nusayhah Hudaa Gopee, Ni Huang, Bayanne Olabi, Chloe Admane, Rachel Anne Botting, April Rose Foster, Fereshteh Torabi, Elena Winheim, Dinithi Sumanaweera, Issac Goh, Mohi Miah, Emily Stephenson, Win Min Tun, Pejvak Moghimi, Benjamin M. Rumney, , Muzlifah A. Haniffa

This study creates a prenatal human skin cell atlas, revealing immune cells' role in skin development and showing their impact on vascular and hair follicle formation.

bioRxiv · Oct 12, 2023 · PreprintDevelopmental Biology

Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome

Laura Jardine, Simone Webb, Issac Goh, Mariana Quiroga Londoño, Gary Reynolds, Michael William Mather, Bayanne Olabi, Emily Stephenson, Rachel Anne Botting, Dave Horsfall, Justin Engelbert, Daniel Maunder, Nicole Mende, Caitlin Murnane, Emma Dann, , Muzlifah A. Haniffa

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

Nature · Sep 29, 2021Peer-reviewedDevelopmental Biology

Decoding the development of the blood and immune systems during human fetal liver haematopoiesis

Dorin-Mirel Popescu, Rachel Anne Botting, Emily Stephenson, Kile Green, Laura Jardine, Emily F. Calderbank, Mirjana Efremova, Meghan J. Acres, Daniel Maunder, Péter Végh, Issac Goh, Yorick Gitton, Jong-Eun Park, Krzysztof Polański, Roser Vento‐Tormo, , Muzlifah A. Haniffa

The paper uses single-cell transcriptomics to map hematopoiesis in human fetal liver, identifying cell differentiation trajectories and shifts in hematopoietic composition during development.

bioRxiv · May 31, 2019 · PreprintDevelopmental Biology