A tonic nicotinic brake controls spike timing in striatal spiny projection neurons
Lior Matityahu, Jeffrey M. Malgady, Meital Schirelman, Yvonne Johansson, Jennifer A. Wilking, Gilad Silberberg, Joshua A. Goldberg, Joshua L. Plotkin
This study shows that tonic activation of 4β2 nicotinic acetylcholine receptors on GABAergic interneurons primes feedforward inhibition, shaping striatal output timing and synaptic plasticity.
eLife · May 17, 2022Peer-reviewedNeuroscience