Author

Ann E. Frazier

The University of MelbourneORCID 0000-0002-6491-3437Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

David A. StroudiD· 2 shared Alejandro Metke· 1 shared Alessandra BrayiD· 1 shared Alexander Charles LewisiD· 1 shared Alexandra M. Birrell· 1 shared Alison G. ComptoniD· 1 shared Andrew H. WeiiD· 1 shared AnneMarie E. WelchiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

David A. StroudORCID

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2 papers

Recent·Most cited

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukaemia.

Alexander Charles Lewis, Emily Gruber, Rheana L. Franich, Jessica M. Armstrong, Madison J. Kelly, Carlos Opazo, Yau Chung Low, Léa Flippe, Kevin Julio Wijanarko, Caitlin L. Rowe, Celeste Mawal, Alexandra M. Birrell, Joan So, Srimayee Vaidyanathan, Keziah Ting, , Lev M. Kats

This study identifies heme biosynthesis as a selective dependency in AML, showing that its inhibition triggers cuproptosis via copper accumulation and reveals synthetic lethal pathways for therapeutic strategies.

Cell · Nov 19, 2025Peer-reviewedCancer Biology

The Australian Genomics Mitochondrial Flagship: A National Program Delivering Mitochondrial Diagnoses

Rocío Rius, Alison G. Compton, Naomi L. Baker, Shanti Balasubramaniam, Stephanie Best, Kaustuv Bhattacharya, Kirsten Boggs, Tiffany F. Boughtwood, Jeffrey Braithwaite, Drago Bratkovic, Alessandra Bray, Marie‐Jo Brion, Jo Burke, Sarah Casauria, Belinda Chong, , David Ross Thorburn

The paper evaluates the diagnostic effectiveness of genomic sequencing in mitochondrial diseases using blood samples, finding a 55% diagnostic yield with higher rates in pediatric cases.

Genetics in Medicine · Sep 19, 2024Peer-reviewedGenetic & Genomic Medicine