Author

Alexander Charles Lewis

The University of MelbourneORCID 0000-0002-6253-5823Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 1

Frequent Co-Authors

Ching‐Seng AngiD· 2 shared Emily GruberiD· 2 shared Lev M. KatsiD· 2 shared Rheana L. FranichiD· 2 shared Alexandra M. Birrell· 1 shared Andrew G SpenceriD· 1 shared Andrew H. WeiiD· 1 shared Ann E. FrazieriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Ching‐Seng AngORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 19, 2026

Menin regulates oncogenic cell identity transcriptional networks in multiple myeloma

Emily Gruber, Subhasree Kumar, Rheana L. Franich…·Lev M. Kats

This study identifies Menin as a key regulator of oncogenic gene expression in multiple myeloma and shows that Menin inhibitors are effective in myeloma cell lines and models.

DOI 10.64898/2026.06.17.733047

humanbulk RNA-seq

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Cancer BiologyCellPeer-reviewedNov 19, 2025

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukaemia.

Alexander Charles Lewis, Emily Gruber, Rheana L. Franich…·Lev M. Kats

This study identifies heme biosynthesis as a selective dependency in AML, showing that its inhibition triggers cuproptosis via copper accumulation and reveals synthetic lethal pathways for therapeutic strategies.

38 citationstop 1%

mousehuman

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