Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk
Phoebe Dace, N. Forrester, Maria Zanti, Laura Cubitt, Chloé Terwagne, Megan Buckley, Elke Maria van Veen, Thomas Stuart Wilson, Paola Scaffidi, Kyriaki Michailidou, Gregory M. Findlay
This study uses saturation genome editing to assess BRCA1 variants across cell types, identifying functionally impactful variants and revealing context-dependent cancer risk.
medRxiv · Aug 11, 2025 · PreprintGenetic & Genomic Medicine