Laura Cubitt

PETRA quantifies regulatory variant effects by editing transcribed regions and measuring mRNA expression changes in human cells.

This study uses saturation genome editing to assess BRCA1 variants across cell types, identifying functionally impactful variants and revealing context-dependent cancer risk.

This paper introduces T2, a method using RNA editing to estimate transcriptional age and identify transient transcriptional programs in human cells.

This study uses Saturation Genome Editing to functionally assess VHL variants, identifying pathogenic alleles and their mechanisms in cancer.

This paper describes a method using DSP fixation to preserve single cells for RNA sequencing, showing it maintains RNA complexity and reduces technical variability.