Author

Megan Buckley

The Francis Crick InstituteORCID 0000-0003-4450-8474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:variant effect prediction· 3 Assay:CRISPR screen· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Gregory M. FindlayiD· 3 shared Chloé TerwagneiD· 2 shared Christina M. KajbaiD· 2 shared Laura CubittiD· 2 shared N. ForresteriD· 2 shared Phoebe DaceiD· 2 shared Ana Cunha· 1 shared Athina GanneriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersGenomics

Gregory M. FindlayORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintAug 11, 2025

Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk

Phoebe Dace, N. Forrester, Maria Zanti…·Gregory M. Findlay

This study uses saturation genome editing to assess BRCA1 variants across cell types, identifying functionally impactful variants and revealing context-dependent cancer risk.

5 citations

humanCRISPR screen

𝕏 PostBluesky

GenomicsCell GenomicsPeer-reviewedMar 22, 2025

High-throughput screening of human genetic variants by pooled prime editing

Michael Herger, Christina M. Kajba, Megan Buckley…·Gregory M. Findlay

This paper introduces a pooled prime editing platform in haploid human cells to assess the functional effects of genetic variants, showing high accuracy in identifying loss-of-function variants and pathogenic non-coding variants.

24 citationstop 2%

humanCRISPR screen

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GenomicsNature GeneticsPeer-reviewedJul 1, 2024

Saturation Genome Editing Resolves the Functional Spectrum of Pathogenic VHL Alleles

Megan Buckley, Chloé Terwagne, Athina Ganner…·Gregory M. Findlay

This study uses Saturation Genome Editing to functionally assess VHL variants, identifying pathogenic alleles and their mechanisms in cancer.

62 citationstop 1%

humanwhole-exome sequencing

𝕏 PostBluesky