Author
The Francis Crick InstituteORCID 0000-0002-3642-4193Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Phoebe Dace, N. Forrester, Maria Zanti…·Gregory M. Findlay
This study uses saturation genome editing to assess BRCA1 variants across cell types, identifying functionally impactful variants and revealing context-dependent cancer risk.
Debosree Pal, Manthan Patel, Fanny Boulet…·Madapura M. Pradeepa
The paper shows H4K16ac activates LINE1 and LTR transcription, contributing to cis-regulatory function by maintaining active chromatin at TEs.
Anob M. Chakrabarti, Tristan Henser‐Brownhill, Josep Monserrat…·Paola Scaffidi
The paper analyzes CRISPR-Cas9 editing precision in human cells, finding that indel profiles vary by site and can be predicted based on sequence and chromatin features.
Thanos P. Mourikis, Lorena Benedetti, Elizabeth Foxall…·on behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium
This study identifies patient-specific cancer genes in esophageal adenocarcinoma using machine learning, revealing recurrent process perturbations that suggest therapeutic targets.