Author

Meri I. E. Uusi-Mäkelä

Karolinska University HospitalORCID 0000-0002-6518-1397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:metagenomics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alina SillanpääiD· 1 shared Anni K. SaralahtiiD· 1 shared Birgitta Henriques‐NormarkiD· 1 shared Cecilia WilliamsiD· 1 shared Gema Sanz· 1 shared Ina Schuppe‐KoistineniD· 1 shared Juliette HayeriD· 1 shared Konstantinos FragkoulisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alina SillanpääORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 31, 2026

Klebsiella pneumoniae T6SS exacerbates gut inflammation promoting tumorigenesis.

Konstantinos Fragkoulis, Meri I. E. Uusi-Mäkelä, Gema Sanz…·Marie‐Stéphanie Aschtgen

This study identifies Klebsiella pneumoniae T6SS as a driver of intestinal inflammation and colorectal tumorigenesis through LPS secretion and immune dysregulation.

DOI 10.64898/2026.03.31.715367

mousezebrafish

𝕏 PostBluesky

ImmunologyDisease Models & MechanismsPeer-reviewedFeb 7, 2025

The inflammasome adaptor pycard is essential for immunity against Mycobacterium marinum infection in adult zebrafish

Meri I. E. Uusi-Mäkelä, Sanna-Kaisa E. Harjula, Maiju Junno…·Mika Rämet

This study shows that pycard is essential for adult zebrafish immunity against Mycobacterium marinum, with impaired survival and increased bacterial burden in pycard-deficient fish.

8 citations

zebrafishbulk RNA-seq

𝕏 PostBluesky