This study sequenced the genome of H. venatoria and analyzed its transcriptome during starvation, revealing expanded P450 gene families and metabolic adaptations for starvation resistance.

bioRxiv · Jul 31, 2024 · PreprintBioinformatics

eQTL mapping in transgenic alpha-synuclein carrying Caenorhabditis elegans recombinant inbred line

Yuqing Huang, Yiru A. Wang, Lisa van Sluijs, Demi H. J. Vogels, Yuzhi Chen, Vivian I. P. Tegelbeckers, Steven Schoonderwoerd, Joost A. G. Riksen, Jan E. Kammenga, Simon Crawford Harvey, Mark G. Sterken

The paper maps eQTLs in a transgenic C. elegans RIL panel to identify genetic modifiers of alpha-synuclein aggregation and PD-related pathways.

bioRxiv · Aug 18, 2023 · PreprintGenomics

Two sides to every coin: reciprocal introgression line populations in Caenorhabditis elegans

Mark G. Sterken, Lisa van Sluijs, Jelle van Creij, Daniel E. Cook, Joost A. G. Riksen, Katharina Jovic, Jasmijn Schouten, M. Steeghs, Yiru A. Wang, Jana J. Stastna, Basten L. Snoek, Simon Crawford Harvey, Jan E. Kammenga

The paper introduces reciprocal introgression line populations in C. elegans to study genetic interactions and complex trait architectures through QTL mapping and expression analysis.

bioRxiv · Aug 29, 2022 · PreprintGenetics

Punctuated loci on chromosome IV determine natural variation in Orsay virus susceptibility of Caenorhabditis elegans strains Bristol N2 and Hawaiian CB4856

Mark G. Sterken, Lisa van Sluijs, Yiru A. Wang, Wannisa Ritmahan, Mitra L. Gultom, Joost A. G. Riksen, Rita J. M. Volkers, Basten L. Snoek, Gorben P. Pijlman, Jan E. Kammenga

The paper identifies two loci on chromosome IV in C. elegans associated with OrV susceptibility, with a single nucleotide polymorphism in cul-6 contributing to the difference between strains.

Journal of Virology · Apr 5, 2021Peer-reviewedGenetics

C. elegans genetic background modifies the core transcriptional response in an α-synuclein model of Parkinson’s disease

Yiru A. Wang, Basten L. Snoek, Mark G. Sterken, Joost A. G. Riksen, Jana J. Stastna, Jan E. Kammenga, Simon Crawford Harvey

BMC Genomics · Mar 20, 2019Peer-reviewedGenomics