Mark G. Sterken

The paper identifies and characterizes a novel resistance haplotype, GpaXIbrc, from Solanum brevicaule that enhances resistance to G. pallida and demonstrates its effectiveness when stacked with other resistance haplotypes.

The paper shows that the nematode Globodera pallida uses environmental cues, specifically sucrose availability, to determine sex, with low sucrose promoting male development and high sucrose promoting female development.

The paper identifies a common genetic basis for G. pallida virulence against GpaVvrn resistance across Western Europe and develops a tool to assess virulence in the field.

This study examines how Arabidopsis adapts its root system architecture to different root-feeding nematodes, revealing distinct compensatory mechanisms for tolerance to biotic stress.

The paper identifies 94 candidate genes in C. elegans linked to susceptibility to 23 environmental toxicants using genome-wide association analysis.

This study identifies a single virulence locus in Globodera pallida that drives resistance breakdown in potato plants through negative selection on an avirulence gene.

The paper identifies viruses in plant-parasitic nematodes and shows they use RNAi to respond to viral infection, with distinct responses between nematode lines.

This study presents a chromosome-scale genome assembly of Meloidogyne hapla, revealing recombination hotspots enriched with effector proteins involved in parasitism.

The paper maps eQTLs in a transgenic C. elegans RIL panel to identify genetic modifiers of alpha-synuclein aggregation and PD-related pathways.

This study investigates how developmental age variation affects eQTL patterns in C. elegans using dynamical eQTL mapping and compares it to classical methods.

The paper identifies susceptibility genes involved in trans-kingdom vitamin B synthesis between a plant-parasitic nematode and its host, revealing a horizontal gene transfer critical for parasitism.

The paper introduces reciprocal introgression line populations in C. elegans to study genetic interactions and complex trait architectures through QTL mapping and expression analysis.

This study identifies QTLs affecting body size and plasticity in C. elegans across different temperatures and developmental stages.

The paper examines genetic variation in the Intracellular Pathogen Response (IPR) in C. elegans, finding balancing selection in key regulators and showing haplotype-specific antiviral defense.

The paper generates two new reference genomes for G. rostochiensis inbred lines and identifies effector family-specific diversification patterns that differ between pathotypes.

The paper identifies two loci on chromosome IV in C. elegans associated with OrV susceptibility, with a single nucleotide polymorphism in cul-6 contributing to the difference between strains.

The paper uses a multi-parental recombinant inbred line population in C. elegans to study gene expression variation and identifies eQTLs and trans-bands affecting gene expression.

The paper shows that conserved codon usage in highly expressed genes correlates with reduced mRNA secondary structure variability, enhancing translation efficiency and mRNA stability.

This study maps eQTL in C. elegans RILs across environments, showing higher reproducibility of local eQTL and environmental effects on eQTL micro-architecture.

WormQTL2 is a database platform that integrates and allows analysis of eQTL datasets in C. elegans to facilitate systems genetics research.

The paper measures transcriptional resilience to heat stress in C. elegans and finds it predicts long-term thermotolerance.

This study develops a multi-parent recombinant inbred line population of C. elegans to improve QTL mapping resolution and identify novel QTLs for life-history traits.

The paper identifies genetic loci controlling metabolite levels in C. elegans using recombinant inbred lines and QTL mapping.

This study examines gene expression changes in C. elegans during heat stress, identifying a critical time window where gene expression shifts and phenotypic damage becomes irreversible.

The paper identifies eQTLs in C. elegans that modulate Ras/MAPK signaling, revealing genetic modifiers that are not detectable in single genetic backgrounds.

The paper investigates how trans regulatory eQTL contribute to cryptic genetic variation in C. elegans under heat stress and recovery conditions.