Author

Belinda S. W. Chang

University of TorontoORCID 0000-0002-6525-4429Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Arthur LeungiD· 1 shared Dr Elizabeth. Gow· 1 shared Jing Liu· 1 shared Rowan F. SageiD· 1 shared Ryan K. SchottiD· 1 shared Steven K. Chen· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 3 mutual co-author links

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1 shared paperPlant Biology

Arthur LeungORCID

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3 papers

Recent·Most cited

Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedOct 30, 2026

Deep Mutational Scanning of the GPCR Rhodopsin Reveals Pleiotropic Mutational Effects and Their Roles in Modulating Light Sensitivity

Steven K. Chen, Jing Liu, Belinda S. W. Chang

The paper uses deep mutational scanning to study pleiotropic effects in rhodopsin, revealing how mutations impact multiple molecular phenotypes and shape light sensitivity.

DOI 10.1073/pnas.2624087123

humanproteomics

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Plant BiologybioRxivPreprintOct 8, 2025

Convergence, stability, and thermal adaptation in the rubisco enzyme in plants

Arthur Leung, Belinda S. W. Chang, Rowan F. Sage

The paper examines RbcL evolution in four plant clades, finding positive selection and convergent substitutions, with stability linked to temperature but weakened after phylogenetic correction.

DOI 10.1101/2025.10.08.681247

plant (other)DNA methylation

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BioinformaticsbioRxivPreprintJan 29, 2019

BlastPhyMe: A toolkit for rapid generation and analysis of protein-coding sequence datasets

Ryan K. Schott, Dr Elizabeth. Gow, Belinda S. W. Chang

BlastPhyMe automates the generation and analysis of protein-coding sequence datasets using a GUI and integrates existing tools for alignment, phylogenetic tree reconstruction, and selection analysis.

7 citations

protein sequencedeep learning

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