Shu‐ou Shan

This study identifies a molecular switch in NAC that prevents mitochondrial protein mistargeting by SRP, showing that mutations disrupt this mechanism and cause ER stress.

The paper identifies NAC's role in promoting co-translational folding by interacting with nascent chains at the ribosomal tunnel exit, expanding its known functions in protein biogenesis.

This study identifies cpSRP43 as a thermo-switchable chaperone that coordinates light harvesting complex biogenesis by switching between closed and open states to support LHCP biogenesis and protect Chl biosynthesis enzymes.