Ahmad Jomaa

This study identifies a zebrafish mutation in ddx49 causing differential cell-type vulnerability in pigment cells due to impaired ribosome biogenesis.

The paper determines the structure of the ribosome stalled by the AMD1 C-tail, revealing how it traps eRF1 and ABCE1 to block translation termination.

This study identifies a molecular switch in NAC that prevents mitochondrial protein mistargeting by SRP, showing that mutations disrupt this mechanism and cause ER stress.

The paper identifies SNOR, a ribosome-associated factor in S. pombe, that enables translation restart after cellular dormancy induced by glucose depletion.

The paper reports the cryo-EM structure of the mammalian SEL1L-HRD1 ERAD core complex, revealing its dimeric organization and how pathogenic mutations disrupt its function and contribute to disease.

This paper introduces DeFrNDs, detergent-free nanodiscs made with engineered membrane scaffold peptides, enabling high-resolution structural analysis of membrane proteins in native lipid environments.

This study identifies hibernating ribosomes tethered to mitochondria as an adaptive response to glucose depletion in fission yeast, showing their role in cell survival.

This study reveals the molecular architecture of the TRAP complex and its interactions with ribosomes and the translocon in ER protein biogenesis.

The paper determines the structure of the translating bacterial ribosome at 1.55 Å resolution using open access cryo-EM, enabling detailed analysis of ribosome polymorphism and drug design.

This study shows SARS-CoV-2 Nsp1 binds to the 40S ribosomal subunit to inhibit translation by blocking mRNA entry, while viral mRNA enhances its own translation.