Gerard J. A. Kroon

This paper designs synthetic proteins that inhibit TLR4 signaling by binding its transmembrane domain, demonstrating the importance of transmembrane interactions in immune signaling.

The paper reports the crystal structure of a GABARAP~ATG3 conjugate, revealing a non-covalent interaction between GABARAP and the backside of ATG3's E2 catalytic center, which is important for PE conjugation.

This study identifies cpSRP43 as a thermo-switchable chaperone that coordinates light harvesting complex biogenesis by switching between closed and open states to support LHCP biogenesis and protect Chl biosynthesis enzymes.

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.