This study identifies the Fpr2-Cd206-TAM receptor axis as a target for pain resolution and fibrinolysis after nerve injury by resealing capillary barriers.

Acta Neuropathologica · Dec 16, 2024Peer-reviewedNeuroscience

Analysis of ovarian transcriptomes reveals thousands of novel genes in the insect vector Rhodnius prolixus

Vitor Lima Coelho, Tarcísio Fontenele de Brito, Ingrid Alexandre de Abreu Brito, Maira Arruda Cardoso, Mateus Antonio Berni, Helena Marcolla Araujo, Michael Sammeth, Attilio Pane

The paper improves the genome and transcriptome of Rhodnius prolixus by identifying over 2,000 novel genes and analyzing stage-specific gene expression during oogenesis.

Scientific Reports · Jan 21, 2021Peer-reviewedBioinformatics

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Alvaro Barbeira, Scott P. Dickinson, Rodrigo Bonazzola, Jiamao Zheng, Heather E. Wheeler, Jason M. Torres, Eric S. Torstenson, Kaanan P. Shah, Tzintzuni Garcia, Todd L. Edwards, Eli Stahl, Laura M. Huckins, François Aguet, Kristin Ardlie, Beryl B. Cummings, , Benjamin J. Strober

The paper develops S-PrediXcan to compute gene expression associations from GWAS summary data and applies it to 44 GTEx tissues and 100+ phenotypes, finding tissue-specific effects and colocalized associations.

Nature Communications · May 2, 2018Peer-reviewedGenomics