Author

Janna Leiz

Max Delbrück CenterORCID 0000-0002-6531-7047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Cell Biology· 1 Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

Kai Martin Schmidt-OttiD· 4 shared Christian HinzeiD· 3 shared Felix J. BoiviniD· 2 shared Karen I. López‐CayuqueoiD· 2 shared Shuang CaoiD· 2 shared Anastasiya BoltengageniD· 1 shared Andreas Christian HockeiD· 1 shared Axel SchambachiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPathology

Kai Martin Schmidt-OttORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

AVPR2 antagonism with tolvaptan alters medullary cell responses and attenuates kidney injury

Karen I. López‐Cayuqueo, Felix J. Boivin, Shuang Cao, Janna Leiz, Larissa Nassauer, Axel Schambach, Christian Hinze, Kai Martin Schmidt-Ott

This study shows that Tolvaptan reduces medullary cell stress and inflammation in kidney injury models.

bioRxiv · Oct 31, 2026 · PreprintPathology

Interleukin enhancer binding factor 2 (Ilf2) and kidney epithelial stress resilience

Shuang Cao, Karen I. López‐Cayuqueo, Janna Leiz, Felix J. Boivin, Marko Lajos, Christian Hinze, Jessica Schmitz, Jan Hinrich Bräsen, Kai M. Schmidt-Ott

This study identifies Ilf2 as a key regulator of kidney epithelial stress resilience through transcriptional and splicing programs in cultured cells and mouse models.

bioRxiv · Aug 12, 2025 · PreprintCell Biology

Discovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks

Sebastian Proft, Janna Leiz, Udo Heinemann, Dominik Seelow, Kai Martin Schmidt-Ott, Maria Rutkiewicz

The paper uses deep learning to identify non-canonical GRHL1 binding sites not detected by traditional PWM methods.

BMC Genomics · Dec 4, 2023Peer-reviewedBioinformatics

Transcriptomic responses of the human kidney to acute injury at single cell resolution

Christian Hinze, Christine Kocks, Janna Leiz, Nikos Karaiskos, Anastasiya Boltengagen, Christopher Mark Skopnik, Jan Klocke, Jan-Hendrik Hardenberg, Helena Stockmann, Inka Gotthardt, Benedikt Obermayer, Laleh Haghverdi, Emanuel Wyler, Markus Landthaler, Sebastian Bachmann, , Kai Martin Schmidt-Ott

This study uses single-nuclei transcriptomics to analyze human kidney injury responses, identifying four injury-associated cell states and showing similar gene expression changes between AKI patients with and without COVID-19.

bioRxiv · Dec 15, 2021 · PreprintMolecular Biology