Axel Schambach

This study shows that Tolvaptan reduces medullary cell stress and inflammation in kidney injury models.

This study shows Septin7 is essential for early hematopoiesis but dispensable at later stages, as its deletion in hematopoietic cells leads to engraftment failure but not steady-state blood lineage defects.

This study shows that base edited universal donor CAR T cells targeting multiple antigens can inhibit AML in mice, with combination therapies needed for heterogeneous disease.

This study shows lentiviral HSPC gene therapy can reverse Pompe disease symptoms in mice by correcting muscle and neurological issues.

This study identifies DNA methylation changes during long-term cell culture that resemble epigenetic drift, linked to chromatin conformation changes.

The paper shows that reprogramming enriches for mutations in cancer-associated genes in hiPSCs, potentially increasing tumor risk.