Andreas Christian Hocke

Overventilation-induced airspace acidification increases susceptibility to Pseudomonas pneumonia

This study shows that high tidal volume ventilation acidifies alveolar lining fluid, increasing susceptibility to Pseudomonas pneumonia by reducing NHE1 expression.

An autologous human iPSC-derived 3D organoid infection model for preclinical testing of antiviral T cells

The paper develops a 3D lung organoid model to assess antiviral T cell efficacy in vitro, demonstrating T cell-mediated cytotoxicity against influenza virus.

Phage-phage competition and biofilms reduce the efficacy of a combination of two virulent bacteriophages against Pseudomonas aeruginosa

This study investigates how phage-phage competition and biofilm formation affect the efficacy of a two-phage combination against Pseudomonas aeruginosa in vitro.

IGF1R is protective in pneumococcal pneumonia

This study shows that IGF1R deficiency worsens pneumococcal pneumonia in mice, with increased lung damage and bacterial load, suggesting IGF1R has a protective role.

VoltRon: A Spatial Omics Analysis Platform for Multi-Resolution and Multi-omics Integration using Image Registration

VoltRon is an R package for spatial omics analysis that integrates multi-resolution and multi-omics data through image registration and spatial alignment.

Transcriptomic responses of the human kidney to acute injury at single cell resolution

This study uses single-nuclei transcriptomics to analyze human kidney injury responses, identifying four injury-associated cell states and showing similar gene expression changes between AKI patients with and without COVID-19.

Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention

The paper uses bulk and single-cell transcriptomics to analyze SARS-CoV-2 infection in human cell lines, identifying HSP90 as a potential therapeutic target.