Tahnee Mackensen

The paper investigates the phenotypic impact of individual conserved neuronal microexons and their regulators in zebrafish, finding that microexon deletions have mild effects while Srrm3/4 loss causes severe neurodevelopmental and behavioral changes.

This study shows that srrm3 regulates arousal states in zebrafish via cAMP signaling, with mutations causing hyperarousal and transcriptional changes.