L. Iñiguez

The paper compares tissue-specific alternative splicing and gene expression across species to show they follow distinct evolutionary routes in repurposing ancestral genes, with TS-AS playing a key role in nervous system diversification.

The paper investigates ZGA timing across 61 animal species and finds that genome size to cytoplasm volume ratio predicts ZGA onset.

The paper investigates the phenotypic impact of individual conserved neuronal microexons and their regulators in zebrafish, finding that microexon deletions have mild effects while Srrm3/4 loss causes severe neurodevelopmental and behavioral changes.

This study develops a tool to analyze transposable element expression in single-cell RNA sequencing data and builds an atlas showing TEs delineate cell types in human PBMCs.

This study shows that srrm3 regulates arousal states in zebrafish via cAMP signaling, with mutations causing hyperarousal and transcriptional changes.

The paper identifies E93 as a repressor of broad (br) to enable adult differentiation in Drosophila by preventing premature activation of pupal-specific enhancers.

The paper investigates the evolution of tissue-specific gene expression across vertebrates and insects, finding that nearly half of ancestral genes have been recruited into tissue-specific transcriptomes.

Insplico quantifies intron splicing order using short and long RNA-seq reads, revealing conserved patterns and novel features across species and tissues.

The paper identifies a microexon program in pancreatic islets regulated by SRRM3, which affects insulin secretion and is linked to type 2 diabetes risk.

Telescope accurately estimates transposable element expression in RNA-seq data by resolving ambiguously mapped fragments using a Bayesian model, revealing cell-type specific retrotranscriptome differences.