Jon Permanyer

Zygotic genome activation is timed by the egg DNA-to-cytoplasm ratio across animals

The paper investigates ZGA timing across 61 animal species and finds that genome size to cytoplasm volume ratio predicts ZGA onset.

Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

The paper investigates the phenotypic impact of individual conserved neuronal microexons and their regulators in zebrafish, finding that microexon deletions have mild effects while Srrm3/4 loss causes severe neurodevelopmental and behavioral changes.

Neural microexons modulate arousal states via cAMP signalling in zebrafish

This study shows that srrm3 regulates arousal states in zebrafish via cAMP signaling, with mutations causing hyperarousal and transcriptional changes.

A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

Evolution of tissue-specific expression of ancestral genes across vertebrates andinsects

The paper investigates the evolution of tissue-specific gene expression across vertebrates and insects, finding that nearly half of ancestral genes have been recruited into tissue-specific transcriptomes.

Specialization of the photoreceptor transcriptome by Srrm3-dependent microexons is required for outer segment maintenance and vision

The paper identifies Srrm3-dependent microexons as critical for photoreceptor function and vision, showing their role in outer segment maintenance and their loss leading to blindness.

Environmental enrichment induces epigenomic and genome organization changes relevant for cognitive function

This study shows environmental enrichment alters chromatin structure, transcription factor binding, and 3D genome organization in mice, affecting cognitive function and gene regulation.

ACME dissociation: a versatile cell fixation-dissociation method for single-cell transcriptomics

The paper introduces ACME, a cell fixation-dissociation method for single-cell transcriptomics that preserves RNA integrity and enables cryopreservation and sorting, validated with SPLiT-seq in planarians.