Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish
Laura López-Blanch, Cristina Rodríguez-Marin, Federica Mantica, L. Iñiguez, Jon Permanyer, Elizabeth M Kita, Tahnee Mackensen, Mireia Codina-Tobias, Francisco Romero-Ferrero, Jordi Fernández‐Albert, Myriam Cuadrado, Xosé R. Bustelo, Gonzalo G. de Polavieja, Manuel Irimia
The paper investigates the phenotypic impact of individual conserved neuronal microexons and their regulators in zebrafish, finding that microexon deletions have mild effects while Srrm3/4 loss causes severe neurodevelopmental and behavioral changes.
eLife · Nov 18, 2025Peer-reviewedMolecular Biology