Author

Taylor N. Takla

University of MichiganORCID 0000-0002-6546-5752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Andrew M. TidballiD· 3 shared J. Clayton Walker· 3 shared Jack M. ParentiD· 3 shared Jinghui LuoiD· 2 shared Roksolana Sudyk· 2 shared Gemma L. CarvilliD· 1 shared Geoffrey G. MurphyiD· 1 shared Jonathan Z. SextoniD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersNeuroscience

Andrew M. TidballORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genome-wide CRISPRi Screen in Human iNeurons to Identify Novel Focal Cortical Dysplasia Genes

Andrew M. Tidball, Jinghui Luo, J. Clayton Walker, Taylor N. Takla, Gemma L. Carvill, Jack M. Parent

The paper uses a CRISPRi screen in human iNeurons to identify novel FCD genes that increase mTOR signaling, finding two genes mutated in FCD patient tissue.

bioRxiv · Dec 13, 2023 · PreprintNeuroscience

A shared pathogenic mechanism for valproic acid and SHROOM3 knockout in a brain organoid model of neural tube defects

Taylor N. Takla, Jinghui Luo, Roksolana Sudyk, Joy Huang, J. Clayton Walker, Neeta L. Vora, Jonathan Z. Sexton, Jack M. Parent, Andrew M. Tidball

This study identifies a shared mechanism of increased lumen size due to reduced apical constriction in brain organoids caused by valproic acid and SHROOM3 knockout.

Cells · Jun 23, 2023Peer-reviewedNeuroscience

Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

Andrew M. Tidball, Wei Niu, Qianyi Ma, Taylor N. Takla, J. Clayton Walker, Joshua L. Margolis, Sandra P. Mojica-Perez, Roksolana Sudyk, Shannon J. Moore, Ravi Chopra, Vikram G. Shakkottai, Geoffrey G. Murphy, Jun Z. Li, Jack M. Parent

The paper describes a method to generate reproducible single-rosette brain organoids from human pluripotent stem cells and uses them to study structural phenotypes in neurodevelopmental disorders.

bioRxiv · Feb 28, 2022 · PreprintNeuroscience