Jonathan Z. Sexton

This study shows that DDE exposure alters cell state and stem cell markers in breast cells, inducing an epidermal phenotype and upregulating keratinization pathways.

This study identifies four DENV inhibitors from a drug library using high-content screening and a pseudotime model to map drug mechanisms onto viral life cycle stages.

This paper uses patient-derived liver organoids and machine learning to identify hepatotoxic compounds by analyzing morphological changes, achieving high accuracy in distinguishing toxicants from non-toxicants.

This paper identifies TgGRA8 as a Toxoplasma protein that recruits ALG-2 to the parasitophorous vacuole, essential for parasite metabolism and ESCRT hijacking.

The paper identifies EAF1 as a Toxoplasma gondii effector that modulates ESCRT subversion using a pooled image-based CRISPR screening framework called spaCR.

This study shows that Salmonella Typhi uses asparaginase to deplete asparagine, activating the GCN2 kinase and the integrated stress response in murine macrophages, which enhances bacterial killing.

This paper uses high-content screening to analyze EBV reactivation and DNA damage response dynamics across multiple B cell models, revealing spatial and kinetic DDR dysregulation during viral replication.

This study investigates how chemical exposures affect biological processes linked to aggressive breast cancer using transcriptomic analysis of normal breast cells from diverse donors.

The paper identifies and characterizes a functional LolB ortholog in Bacteroides that rescues E. coli's lethal phenotype and shows its role in lipoprotein transport.

VISTA-FISH links live-cell imaging with gene expression in neurons to study differentiation and cellular activity.

This paper develops a long-term in vitro model of human colonic epithelium that maintains barrier function for up to 30 days and responds to various challenges.

This study shows neutrophils release nuclear DNA via exosomes to resolve sterile inflammation, with implications for treating inflammatory diseases.

This study examines how different levels of lead exposure affect neural differentiation in SH-SY5Y cells, showing significant changes in protein expression and cell morphology.

LUMIC generates high-quality cell images using diffusion models and self-supervised learning, outperforming existing methods across cell lines and treatments.

This paper identifies and characterizes Lnb, a lipoprotein N-acyltransferase in Bacteroides, showing its role in lipoprotein biosynthesis and its impact on bacterial growth and polysaccharide degradation.

The paper uses Cell Painting to assess the morphological effects of 16 chemicals and 21 small molecules on MCF10A cells, identifying shared and distinct features and linking some to Wnt pathway activation.

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

This study identifies opposing roles for TGFbeta and BMP signaling in generating AT2-like cells from lung progenitors in vitro.

This study identifies a shared mechanism of increased lumen size due to reduced apical constriction in brain organoids caused by valproic acid and SHROOM3 knockout.

The paper identifies EPIREGULIN as a niche factor that enables spatial organization in human intestinal organoids, mimicking the native intestine's structure and gene expression.

This study uses CRISPR screening to identify 35 genes that modify ACE2 surface abundance in HuH7 cells, revealing regulators of ACE2 expression and their impact on SARS-CoV-2 susceptibility.

This study quantifies 4D nuclear morphology changes in human astrocytes treated with valproic acid, showing significant size and shape differences by day 7.