Author

J. Clayton Walker

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andrew M. TidballiD· 4 shared Jack M. ParentiD· 4 shared Taylor N. TaklaiD· 3 shared Jinghui LuoiD· 2 shared Joshua L. Margolis· 2 shared Roksolana Sudyk· 2 shared Aiswarya SaravananiD· 1 shared Amrita Kondur· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersNeuroscience

Andrew M. TidballORCID

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5 papers

Recent·Most cited

Delayed forebrain excitatory and inhibitory neurogenesis inSTRADA-related megalencephaly via mTOR hyperactivity

Tong Pan, Grace Lin, Xuan Li, Debora VanHeyningen, J. Clayton Walker, Sahej Kohli, Aiswarya Saravanan, Amrita Kondur, Daniel C. Jaklic, Saul Pantoja-Gutierrez, Shivanshi Vaid, Julie S. Sturza, Ken Inoki, Tomozumi Imamichi, Weizhong Chang, Louis T. Dang

This study shows that mTOR hyperactivity in STRADA-deficient brain organoids causes delayed neurogenesis and altered interneuron fate, which can be rescued by rapamycin.

Stem Cell Reports · Mar 5, 2026Peer-reviewedNeuroscience

Genome-wide CRISPRi Screen in Human iNeurons to Identify Novel Focal Cortical Dysplasia Genes

Andrew M. Tidball, Jinghui Luo, J. Clayton Walker, Taylor N. Takla, Gemma L. Carvill, Jack M. Parent

The paper uses a CRISPRi screen in human iNeurons to identify novel FCD genes that increase mTOR signaling, finding two genes mutated in FCD patient tissue.

bioRxiv · Dec 13, 2023 · PreprintNeuroscience

A shared pathogenic mechanism for valproic acid and SHROOM3 knockout in a brain organoid model of neural tube defects

Taylor N. Takla, Jinghui Luo, Roksolana Sudyk, Joy Huang, J. Clayton Walker, Neeta L. Vora, Jonathan Z. Sexton, Jack M. Parent, Andrew M. Tidball

This study identifies a shared mechanism of increased lumen size due to reduced apical constriction in brain organoids caused by valproic acid and SHROOM3 knockout.

Cells · Jun 23, 2023Peer-reviewedNeuroscience

Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

Andrew M. Tidball, Wei Niu, Qianyi Ma, Taylor N. Takla, J. Clayton Walker, Joshua L. Margolis, Sandra P. Mojica-Perez, Roksolana Sudyk, Shannon J. Moore, Ravi Chopra, Vikram G. Shakkottai, Geoffrey G. Murphy, Jun Z. Li, Jack M. Parent

The paper describes a method to generate reproducible single-rosette brain organoids from human pluripotent stem cells and uses them to study structural phenotypes in neurodevelopmental disorders.

bioRxiv · Feb 28, 2022 · PreprintNeuroscience

Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons

Andrew M. Tidball, Luis F. Lopez‐Santiago, Yukun Yuan, Trevor W. Glenn, Joshua L. Margolis, J. Clayton Walker, Emma G. Kilbane, Lori L. Isom, Jack M. Parent

This study uses patient-derived iPSC neurons to show variant-specific changes in sodium currents in SCN8A-EIEE13, identifying altered persistent and resurgent INa and potential therapeutic responses.

bioRxiv · Jan 16, 2020 · PreprintNeuroscience