Youwen Yang

Redox-activated induction of Warburg-type metabolism in the adult heart

The paper shows NOX4 induces Warburg-type metabolic reprogramming in the healthy adult heart, balancing energy and anabolic demands through transcriptional and epigenetic mechanisms.

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

This study identifies DNA methylation changes associated with extreme obesity and finds causal effects on obesity and metabolic disturbances using Mendelian Randomisation.

A gene regulatory network for neural induction

The paper constructs a gene regulatory network for neural induction using transcriptomics and epigenomics data, revealing 175 regulators and 5,614 interactions with temporal dynamics.

A 3D molecular atlas of the chick embryonic heart

The paper creates a 3D molecular atlas of the chick embryonic heart at HH12 by analyzing gene expression in 13 micro-dissected regions and validating findings with in situ hybridisation and imaging techniques.