Mauro Giacca

This study investigates miR-378a's role in cardiomyocyte metabolism, mitochondrial function, and angiogenic signaling, showing its impact on cardiac performance and limited therapeutic benefit from overexpression.

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

This study shows how varying TBX5 levels in cardiomyocytes affects their maturation, specialization, and dedifferentiation, revealing a non-linear relationship with cardiac function.

This study shows that dietary glutamine reduces H3K27me3 levels in aged mice, improving cardiac function by enhancing autophagy and metabolic health.

This study shows that inhibiting Runx1 protects against heart failure with preserved ejection fraction in mice by improving diastolic function and reducing hypertrophy and pulmonary edema.

The paper identifies seven novel miRNAs that inhibit vascular smooth muscle cell proliferation without inducing apoptosis or senescence.

This study identifies miR-106b~25 as a regulator of cardiomyocyte hyperplasia to hypertrophy transition and shows its ability to induce cardiac regeneration in adult mice.

This study shows that delivering SREBP2 to astrocytes in HD mice restores cholesterol biosynthesis and improves disease symptoms.