Ablation of glypican-3 enhances radiosensitivity in liver cancer by prolonging G2/M arrest and activating the ATM/CHK2 pathway
Joon‐Yong Chung, Hima Makala, Woong Hee Lee, Olivia W. Lee, Simran Khurana, Jeong Won Kim, Julia Sheehan‐Klenk, Divya Nambiar, Stanley Fayn, Ayla O. White, Eun Joo Chung, Nada Alani, Sabrina Ramelli, Stephen M. Hewitt, Travis H. Stracker, , Freddy E. Escorcia
This study shows that reducing GPC3 in liver cancer cells increases their sensitivity to radiation by extending G2/M arrest and activating the ATM/CHK2 pathway, with clinical evidence linking high GPC3 to worse outcomes in radiotherapy-treated HCC patients.
bioRxiv · May 14, 2026 · PreprintCancer Biology