Travis H. Stracker

This study identifies G-quadruplex DNA as a key factor in homologous recombination, showing that DHX36 suppresses G4-mediated HR and its loss enhances repair and promotes ALT.

The paper identifies CDK2 substrates in mouse ESCs, revealing HMCES phosphorylation's role in AP-site repair and ESC proliferation.

This study shows that reducing GPC3 in liver cancer cells increases their sensitivity to radiation by extending G2/M arrest and activating the ATM/CHK2 pathway, with clinical evidence linking high GPC3 to worse outcomes in radiotherapy-treated HCC patients.

This study identifies PRDX1's role in preventing oxidative damage to the nucleolar genome by maintaining rDNA transcription and ribosome biogenesis.

The paper develops an Optical Pooled Screen (OPS) assay using telomeric native DNA FISH to measure ALT pathway activity and identifies regulators of the ALT pathway.

This study identifies novel genes that modulate the ALT pathway using a high-throughput imaging screen, revealing both promoting and inhibiting factors and demonstrating pharmacological modulation potential.

The paper identifies a de novo TLK1 mutation linked to neurodevelopmental disorder and immunodeficiency, showing impaired kinase activity and altered cytokine responses.

This study identifies SIRT1's role in regulating DNA damage signaling via interaction with the PP4 phosphatase complex, showing SIRT1 inhibits PP4 to modulate key DDR markers.

This study investigates the effects of ADSL deficiency on neurodevelopment, showing both SAICAr-dependent and independent mechanisms contributing to pathologies like microcephaly and autism.

This study shows TLK1/2 activity protects replication forks, contributes to chromatin silencing, and suppresses innate immune responses, with implications for immune evasion in chromosomally unstable cancers.

The paper shows that GEMC1 and CCNO are essential for efferent duct development and male fertility in mice, with defects in multiciliated cell formation leading to infertility.