Simran Khurana

This study identifies G-quadruplex DNA as a key factor in homologous recombination, showing that DHX36 suppresses G4-mediated HR and its loss enhances repair and promotes ALT.

This study shows that reducing GPC3 in liver cancer cells increases their sensitivity to radiation by extending G2/M arrest and activating the ATM/CHK2 pathway, with clinical evidence linking high GPC3 to worse outcomes in radiotherapy-treated HCC patients.

This study identifies novel genes that modulate the ALT pathway using a high-throughput imaging screen, revealing both promoting and inhibiting factors and demonstrating pharmacological modulation potential.