Compressive mechanical stress activates ERK5 to regulate cortical tension and promote invasive cellular traits
Nevena Srejić, Frank van Drogen, Tatjana Sajic, Federico Uliana, Matthias Peter
The paper shows compressive mechanical stress activates ERK5, which reduces cortical tension and promotes cell invasion by inhibiting myosin through MYPT1.
bioRxiv · Feb 2, 2026 · PreprintCell Biology