Matthias Peter

PKA-regulated carbohydrate production protects cells by altering cytoplasmic biophysical properties

This study shows PKA regulates cytoplasmic density by controlling glycogen and trehalose, which affect diffusion and confer stress resistance.

Systematic identification of pH-sensing amyloid core motifs reveals a widespread mechanism for reversible protein assembly upon stress

The paper identifies pH-sensing amyloid core motifs in yeast and human proteomes, showing they enable reversible protein assembly under stress.

Molecular determinants underlying substrate receptor specificity of human CRL4B E3 ubiquitin ligase

This study identifies molecular determinants that guide DCAF specificity for CUL4B in the CRL4B E3 ubiquitin ligase complex through structural and biochemical analyses.

Compressive mechanical stress activates ERK5 to regulate cortical tension and promote invasive cellular traits

The paper shows compressive mechanical stress activates ERK5, which reduces cortical tension and promotes cell invasion by inhibiting myosin through MYPT1.

Disruption of nucleolar integrity triggers cellular quiescence through organelle rewiring and secretion

This study identifies a stress response pathway linking nucleolar disruption to cellular quiescence and secretion, revealing its role in cancer progression.

PKA regulates stress granule maturation to allow timely recovery after prolonged starvation

This paper shows that PKA-dependent phosphorylation drives stress granule maturation during prolonged starvation, delaying disassembly and promoting cell survival.

Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy

This study identifies Stm1's role in promoting ribosome biogenesis by regulating Ifh1 activity, revealing a link between ribosome biogenesis and dormancy.

Systematic dissection of phosphorylation-dependent YAP1 complex formation elucidates a key role for PTPN14 in Hippo signal integration

The paper develops an experimental strategy to link phosphorylation events with protein complex formation, revealing PTPN14's role in regulating YAP1's interaction with LATS1/2 kinases.

Positive feedback induces switch between distributive and processive phosphorylation of Hog1

The paper investigates the phosphorylation mechanism of Hog1 in yeast, finding that positive feedback enables a switch between distributive and processive phosphorylation, enhancing sensitivity and robustness.

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

The paper identifies structural and kinetic mechanisms of COP9-Signalosome activation and Nedd8 deconjugation in cullin-RING ubiquitin ligase deneddylation.