Federico Uliana

This study investigates how TDP-43 phase separation affects its protein interactome and regulation of alternative splicing, showing PS-dependent interactions with RNA regulators.

The paper identifies pH-sensing amyloid core motifs in yeast and human proteomes, showing they enable reversible protein assembly under stress.

This study identifies Jjj2 as a chaperone that regulates nucleoporin condensation in budding yeast, showing its role in maintaining NPC permeability and preventing aggregation.

The paper identifies a low-affinity KDK motif in Kar9 that specializes +TIP body function by modulating microtubule dynamics through multivalent interactions with Bik1.

This study shows that cell wall remodeling via the CWI pathway maintains cytoplasmic crowding homeostasis during yeast cell growth.

This study identifies molecular determinants that guide DCAF specificity for CUL4B in the CRL4B E3 ubiquitin ligase complex through structural and biochemical analyses.

The paper shows compressive mechanical stress activates ERK5, which reduces cortical tension and promotes cell invasion by inhibiting myosin through MYPT1.

This study identifies CLCC1 as a Torsin1A binding partner essential for nuclear envelope membrane fusion during NPC biogenesis, showing its therapeutic potential for DYT1 dystonia.

This study identifies a stress response pathway linking nucleolar disruption to cellular quiescence and secretion, revealing its role in cancer progression.

This study shows that SARS-CoV-2 main protease (Mpro) activates coagulation factors VII and XII, increasing plasma clotting probability by 2.5-fold.

This study shows that TDP-43 and Tau directly interact, promoting co-condensation but reducing Tau fibril formation and seeding.

This paper shows that PKA-dependent phosphorylation drives stress granule maturation during prolonged starvation, delaying disassembly and promoting cell survival.

This study identifies Stm1's role in promoting ribosome biogenesis by regulating Ifh1 activity, revealing a link between ribosome biogenesis and dormancy.

This study investigates the phase separation of Bik1, a +TIP protein, revealing its conformational changes and fractal structure in liquid condensates.

This study shows that VMP1 and TMEM41b are required for primitive endoderm specification by regulating WNT signaling in mouse ESCs.

DIP-MS resolves protein complex isoforms using deep learning and mass spectrometry, revealing new subunits in human prefoldin complexes.

The paper presents an integrated experimental and computational strategy to model protein-protein interactions in cellular context, applied to the TNF-receptor signaling complex.

The paper develops an experimental strategy to link phosphorylation events with protein complex formation, revealing PTPN14's role in regulating YAP1's interaction with LATS1/2 kinases.

The paper presents a rapid workflow combining experimental and computational methods to profile protein complex re-organization in cellular states, showing distinct changes during differentiation and macrophage stimulation.

The paper introduces PCprophet, a computational framework for identifying and analyzing protein complexes from co-fractionation mass spectrometry data across conditions.