Structural insights into transcriptional regulation by the helicase RECQL5
Alfredo Jose Florez Ariza, Nicholas Z. Lue, Patricia Grob, Benjamin Kaeser, Jie Fang, Susanne A. Kassube, Eva Nogales
This study determines the structure of RECQL5-bound Pol II elongation complexes using cryo-EM, revealing how RECQL5 stabilizes Pol II and modulates its translocation state to reduce transcription stress.
Nature Structural & Molecular Biology · Jul 7, 2025Peer-reviewedMolecular Biology