Molecular BiologyNature Structural & Molecular BiologyPeer-reviewed
Structural insights into transcriptional regulation by the helicase RECQL5
Alfredo Jose Florez Ariza, Nicholas Z. Lue, Patricia Grob…·Eva Nogales
This study determines the structure of RECQL5-bound Pol II elongation complexes using cryo-EM, revealing how RECQL5 stabilizes Pol II and modulates its translocation state to reduce transcription stress.