Leishmanial GP63 acts as a protease for the small pore forming toxin aerolysin
Chaitanya S. Haram, Sebastian J. Salinas, Salma Waheed Sheikh, Kai Zhang, Peter A. Keyel
This study identifies GP63 as a protease that activates aerolysin toxin in Leishmania major, revealing a mechanism of bacterial competition in the sandfly midgut.
bioRxiv · Jul 30, 2026 · PreprintCell Biology