Author

Zainab Hussain

Centre National de la Recherche ScientifiqueORCID 0000-0002-5641-5569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christina S. LeslieiD· 1 shared Christophe LachaudiD· 1 shared Coralie Compare· 1 shared Dig Vijay Kumar YarlagaddaiD· 1 shared Eugénie Lohmann· 1 shared Fabienne GuillaumondiD· 1 shared François BertucciiD· 1 shared Georgios EfthymiouiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Christina S. LeslieORCID

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2 papers

Recent·Most cited

Invasion status stratifies the composition of the human pancreatic cancer perineural niche

Zainab Hussain, Dig Vijay Kumar Yarlagadda, Qianzi Li, Nuray Tezcan, Pavel Stupakov, Golabahar Sadatrezaei, Richard J. Wong, Joan Massagué, Zeynep Cagla Tarcan, Olca Baştürk, Sylvie Deborde, Christina S. Leslie, Mara H. Sherman

Xenium and single-nucleus profiling of 14 human pancreatic tumors shows invaded nerve neighborhoods enriched for classical cancer cells, myCAFs and lipid-handling macrophages but depleted of lymphocytes.

bioRxiv · Aug 6, 2026 · PreprintCancer Biology✦ In-depth digest

The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage.

Georgios Efthymiou, Coralie Compare, Eugénie Lohmann, Paraskevi Kousteridou, Pierre Marie Bertrand, Heather S. Carr, Issam Ben‐Sahra, Ivan Nemazanyy, Sarah-Simha Tubiana, Zainab Hussain, Pascal Finetti, François Bertucci, Ghislain Bidaut, Christophe Lachaud, Fabienne Guillaumond, , Sophie Vasseur

This study shows that the extracellular matrix promotes guanylate production in pancreatic cancer cells, reducing oxaliplatin-induced DNA damage and enhancing proliferation.

Science Advances · Dec 12, 2025Peer-reviewedCancer Biology