A Bi-Specific T Cell-Engaging Antibody Shows Potent Activity, Specificity, and Tumor Microenvironment Remodeling in Experimental Syngeneic and Genetically Engineered Models of GBM
Μαρκέλλα Ζαννίκου, Joseph T. Duffy, Daniele Procissi, Hinda Najem, Rebecca Levine, Aditi Thakur, Dolores Hambardzumyan, Catalina Lee-Chang, Lara Leoni, Craig Horbinski, Dmitri Simberg, Bin Zhang, Amy B. Heimberger, Jason M. Miska, Irina V. Balyasnikova
This study evaluates a bispecific T cell-engaging antibody in immunocompetent GBM models, showing improved survival, TME remodeling, and immune memory induction.
Journal for ImmunoTherapy of Cancer · Oct 1, 2025Peer-reviewedImmunology