Paul Brent Ferrell

This study identifies somatic DDX41 mutations as gain-of-function alleles that drive aberrant splicing, particularly of SEPTIN7, contributing to MDS/AML pathogenesis.

This study identifies CDK8 mis-splicing as a driver of altered progenitor fate in SF3B1-mutant MDS, linking splicing defects to transcriptional dysregulation and lineage commitment.

This study profiles single-cell multiomic data from clonal hematopoiesis patients and controls, revealing pro-inflammatory profiles in monocytes and T cell dysfunction.