In vivo sequential mutagenesis in germinal center B cells using a dual-recombinase approach: FOXO1 re-expression upon FOXO1 knockout rescues class switch recombination
Carlota Farré Díaz, Eleni Kabrani, Wiebke Winkler, Eric Blanc, Brigitte Wollert‐Wulf, Claudia Salomon, F. Thomas Wunderlich, Dieter Beule, Martin Janz, Klaus Rajewsky
The paper introduces a dual-recombinase system for sequential mutagenesis in germinal center B cells, enabling FOXO1 knockout and subsequent re-expression to study its effects on class switch recombination.
The Journal of Experimental Medicine · Dec 3, 2025Peer-reviewedImmunology