F. Thomas Wunderlich

ConvexGating infers gating strategies from clusters in single cell cytometry data

ConvexGating automatically learns unbiased, interpretable gating strategies for flow cytometry data, improving consistency and reducing contamination in cell population identification.

Targeting soluble immunoglobulins ameliorates idiopathic multicentric Castleman disease in a mouse model

This paper develops a mouse model of idiopathic multicentric Castleman disease (iMCD) by targeting IL-6 to Foxp3+ Treg cells, showing that reducing soluble immunoglobulin production alleviates disease symptoms and improves survival.

Downregulation of Satb1 is required to prevent autoimmunity by maintaining Tfh homeostasis

This study shows that Satb1 downregulation prevents autoimmunity by maintaining Tfh cell homeostasis and preventing excessive GC formation and auto-antibody secretion.

In vivo sequential mutagenesis in germinal center B cells using a dual-recombinase approach: FOXO1 re-expression upon FOXO1 knockout rescues class switch recombination

The paper introduces a dual-recombinase system for sequential mutagenesis in germinal center B cells, enabling FOXO1 knockout and subsequent re-expression to study its effects on class switch recombination.

Single-Cell Resolution of Cellular Damage Illuminates Disease Progression

The paper develops single-cell damage scores to quantify cellular deterioration in degenerative diseases and applies them to murine and human datasets to identify molecular trajectories of damage.

TET3 regulates cellular terminal differentiation at the metabolic level

This study shows TET3 regulates terminal differentiation by affecting mitochondrial metabolic maturation and oxidative phosphorylation in intestinal epithelial cells.