Eric M. Jones

This study applies high-resolution deep mutational scanning to the melanocortin-4 receptor to identify functionally significant variants and guide drug development.

This study uses deep mutational scanning to analyze GPCR variants, identifying key residues for signaling and function across multiple GPCR classes.

The paper investigates how transcription factor binding site architecture influences transcriptional activity using synthetic regulatory elements in a massively parallel reporter assay.

The paper develops a high-throughput platform to screen chemical libraries against receptor repertoires, identifying novel receptor-ligand interactions.

The paper identifies rare genetic variants that cause large disruptions to exon recognition, using a new assay called MFASS, and finds most of these variants are not in canonical splice sites.