Author
University of California, Los AngelesORCID 0000-0001-8064-2465Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Conor J Howard, Nathan S. Abell, Beatriz A. Osuna…·Nathan B. Lubock
This study applies high-resolution deep mutational scanning to the melanocortin-4 receptor to identify functionally significant variants and guide drug development.
W. Clifford Boldridge, Ajasja Ljubetič, Hwangbeom Kim…·Sriram Kosuri
The paper develops a high-throughput method to characterize protein-protein interactions and design orthogonal coiled-coil pairs, identifying a large set of specific interactions.
Eric M. Jones, Nathan B. Lubock, AJ Venkatakrishnan…·Sriram Kosuri
This study uses deep mutational scanning to analyze GPCR variants, identifying key residues for signaling and function across multiple GPCR classes.
Angus M. Sidore, Calin Plesa, Joyce Samson…·Sriram Kosuri
DropSynth 2.0 improves gene synthesis fidelity and scale by optimizing enzymes and adding error correction in emulsions.
Eric M. Jones, Rishi Jajoo, Daniel Cancilla…·Sriram Kosuri
The paper develops a high-throughput platform to screen chemical libraries against receptor repertoires, identifying novel receptor-ligand interactions.
Nathan B. Lubock, Di Zhang, Angus M. Sidore…·Sriram Kosuri
The paper quantifies error correction in gene synthesis using next-generation sequencing, finding ErrASE and T7 Endonuclease I most effective at reducing error rates.